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COSTANTINI PAOLA: PUBBLICAZIONI

1 Petronilli V, Nicolli A, Costantini P, Colonna R, Bernardi P.
Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A.
BIOCHIM BIOPHYS ACTA. Aug 1994; 1187(2): 255-9
2 Petronilli V, Costantini P, Scorrano L, Colonna R, Passamonti S, Bernardi P.
The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents.
J BIOL CHEM. Jun 1994; 269(24): 16638-42
3 Petronilli V, Nicolli A, Costantini P, Colonna R, Bernardi P.
The permeability transition pore. Pathophysiology of a cyclosporin A-sensitive mitochondrial channel.
Modern Trends in BioKinetics. 1994; 3: 259-262
4 Nicolli A, Costantini P, Basso E, Colonna R, Petronilli V, Bernardi P.
Potential role of cyclosporin A-sensitive mitochondrial channels in ischemia-reperfusion injury.
TRANSPLANT P. Oct 1995; 27(5): 2825-6
5 Costantini P, Petronilli V, Colonna R, Bernardi P.
On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide.
TOXICOLOGY. May 1995; 99(1-2): 77-88
6 Costantini P, Chernyak BV, Petronilli V, Bernardi P.
Selective inhibition of the mitochondrial permeability transition pore at the oxidation-reduction sensitive dithiol by monobromobimane.
FEBS LETT. Apr 1995; 362(2): 239-42
7 Costantini P, Chernyak BV, Petronilli V, Bernardi P.
Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites.
J BIOL CHEM. Mar 1996; 271(12): 6746-51
8 Bernardi P, Colonna R, Costantini P, Eriksson O, Fontaine E, Ichas F, Massari S, Nicolli A, Petronilli V, Scorrano L.
The mitochondrial permeability transition.
BIOFACTORS. 1998; 8(3-4): 273-81
9 Costantini P, Colonna R, Bernardi P.
Induction of the mitochondrial permeability transition by N-Ethylmaleimide depends on secondary oxidation of critical thiol groups. Potentiation by copper-ortho-phenantroline without dimerization of the adenine nucleotide translocase.
BBA-BIOENERGETICS. 1998; 1365: 385-392
10 Bernardi P, Basso E, Colonna R, Costantini P, Di Lisa F, Eriksson O, Fontaine E, Forte M, Ichas F, Massari S, Nicolli A, Petronilli V.
Perspectives on the mitochondrial permeability transition.
BBA-BIOENERGETICS. 1998; 1365: 200-2006
11 Marchetti P, Zamzami N, Joseph B, Schraen-maschke S, Méreau-richard C, Costantini P, Métivier D, Susin SA, Kroemer G, Formstecher P.
The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.
CANCER RES. Dec 1999; 59(24): 6257-66
12 Jacotot E, Costantini P, Laboureau E, Zamzami N, Susin SA, Kroemer G.
Mitochondrial membrane permeabilization during the apoptotic process.
ANN NY ACAD SCI. 1999; 887: 18-30
13 Ravagnan L, Marzo I, Costantini P, Susin SA, Zamzami N, Petit PX, Hirsch F, Goulbern M, Poupon MF, Miccoli L, Xie Z, Reed JC, Kroemer G.
Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore.
ONCOGENE. Apr 1999; 18(16): 2537-46
14 Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G.
Molecular characterization of mitochondrial apoptosis-inducing factor.
NATURE. Feb 1999; 397(6718): 441-6
15 Bernardi P, Colonna R, Costantini P, Eriksson O, Nicolli A, Petronilli V, Scorrano L.
Chemical modification of the mitochondrial permeability transition pore by specific amino acid reagents.
DRUG DEVELOP RES. 1999; 46: 14-17
16 De Pablo M, Susin SA, Jacotot E, Larochette N, Costantini P, Ravagnan L, Zamzami N, Kroemer G.
Palmitate induces apoptosis via a direct effect on mitochondria.
APOPTOSIS. 1999; 4: 81-87
17 Rippo MR, Malisan F, Ravagnan L, Tomassini B, Condò I, Costantini P, Susin SA, Rufini A, Todaro M, Kroemer G, Testi R.
GD3 ganglioside as an intracellular mediator of apoptosis.
EUR CYTOKINE NETW. Sep 2000; 11(3): 487-8
18 Zamzami N, El Hamel C, Maisse C, Brenner C, Muñoz-pinedo C, Belzacq AS, Costantini P, Vieira H, Loeffler M, Molle G, Kroemer G.
Bid acts on the permeability transition pore complex to induce apoptosis.
ONCOGENE. Dec 2000; 19(54): 6342-50
19 Rippo MR, Malisan F, Ravagnan L, Tomassini B, Condo I, Costantini P, Susin SA, Rufini A, Todaro M, Kroemer G, Testi R.
GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion.
FASEB J. Oct 2000; 14(13): 2047-54
20 Susin SA, Daugas E, Ravagnan L, Samejima K, Zamzami N, Loeffler M, Costantini P, Ferri KF, Irinopoulou T, Prévost MC, Brothers G, Mak TW, Penninger J, Earnshaw WC, Kroemer G.
Two distinct pathways leading to nuclear apoptosis.
J EXP MED. Aug 2000; 192(4): 571-80
21 Costantini P, Jacotot E, Decaudin D, Kroemer G.
Mitochondrion as a novel target of anticancer chemotherapy.
J NATL CANCER I. Jul 2000; 92(13): 1042-53
22 Costantini P, Belzacq AS, Vieira HL, Larochette N, De Pablo MA, Zamzami N, Susin SA, Brenner C, Kroemer G.
Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis.
ONCOGENE. Jan 2000; 19(2): 307-14
23 Jacotot E, Ravagnan L, Loeffler M, Ferri KF, Vieira HL, Zamzami N, Costantini P, Druillennec S, Hoebeke J, Briand JP, Irinopoulou T, Daugas E, Susin SA, Cointe D, Xie ZH, Reed JC, Roques BP, Kroemer G.
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.
J EXP MED. Jan 2000; 191(1): 33-46
24 Miramar MD, Costantini P, Ravagnan L, Saraiva LM, Haouzi D, Brothers G, Penninger JM, Peleato ML, Kroemer G, Susin SA.
NADH oxidase activity of mitochondrial apoptosis-inducing factor.
J BIOL CHEM. May 2001; 276(19): 16391-8
25 Costantini P, Bruey JM, Castedo M, Métivier D, Loeffler M, Susin SA, Ravagnan L, Zamzami N, Garrido C, Kroemer G.
Pre-processed caspase-9 contained in mitochondria participates in apoptosis.
CELL DEATH DIFFER. Jan 2002; 9(1): 82-8
26 Johans M, Milanesi E, Franck M, Johans C, Liobikas J, Panagiotaki M, Greci L, Principato G, Kinnunen PK, Bernardi P, Costantini P, Eriksson O.
Modification of permeability transition pore arginine(s) by phenylglyoxal derivatives in isolated mitochondria and mammalian cells. Structure-function relationship of arginine ligands.
J BIOL CHEM. Jan 2005
27 Tosatto SC, Giacometti GM, Valle G, Costantini P.
Functional insights from the structural modelling of a small Fe-hydrogenase.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Nov 2005
28 Segalla A, Szabò I, Costantini P, Giacometti GM.
Study of the effect of ion channel modulators on photosynthetic oxygen evolution.
J CHEM INF MODEL. NOV 2005; 45(6): 1691-700
29 Milanesi E, Costantini P, Gambalunga A, Colonna R, Petronilli V, Cabrelle A, Semenzato G, Cesura AM, Pinard E, Bernardi P.
The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative.
J BIOL CHEM. APR 2006; 281(15): 10066-10072
30 Tosatto SCE, Toppo S, Carbonera D, Giacometti GM, Costantini P.
Comparative analysis of Fe-only hydrogenase from Thermotogales indicates the molecular basis of resistance to oxygen inactivation.
INT J HYDROGEN ENERG. 2008; 33: 570-578